Actualités du laboratoire Hesper

- Alexandra Dima, Julie Haesebaert, Adèle Perrin, Luiza Siqueira Do Prado, Anne-Marie Schott-Pethelaz : « What is Patient and Public Involvement in Research and how to do it? »

Patient oriented research – Key features and RESHAPE guidelines

Nowadays, partnering with patients in health research is strongly recommended. Patient and Public Involvement (PPI) in research is defined as research actively carried out ‘with’ or ‘by’ members of the public rather than ‘to’, ‘about’, or ‘for’ them (INVOLVE group UK). In 2015, as part of the patient partnership strategy,

The BMJ began requiring authors to include a PPI statement in all research articles. In the year before the PPI reporting requirement, 0.5% of research articles reported PPI activity. In the year following the requirement, 11% of research articles reported PPI activity (Price A, BMJ 2018). In France, researchers awareness about PPI in research is less developed. Our presentation aims to disseminate these approaches within RESHAPE projects. After presenting the foundations and benefits of partnership in research, we will propose a guide and tools designed to support RESHAPE researchers and patients to engage in partnership in research.

Bertrand A, Aho S, Rousset-Jablonski C, Cessot M, Christophe V, Marec-Bérard P, Ray-Coquard I.

Abstract:

It is well recognised that adolescents and young adults (AYA) with cancer have inequitable access to oncology services that provide expert cancer care and consider their unique needs. Subsequently, survival gains in this patient population have improved only modestly compared with older adults and children with cancer. In 2015, the European Society for Medical Oncology (ESMO) and the European Society for Paediatric Oncology (SIOPE) established the joint Cancer in AYA Working Group in order to increase awareness among adult and paediatric oncology communities, enhance knowledge on specific issues in AYA and ultimately improve the standard of care for AYA with cancer across Europe. This manuscript reflects the position of this working group regarding current AYA cancer care, the challenges to be addressed and possible solutions. Key challenges include the lack of specific biological understanding of AYA cancers, the lack of access to specialised centres with age-appropriate multidisciplinary care and the lack of available clinical trials with novel therapeutics. Key recommendations include diversifying interprofessional cooperation in AYA care and specific measures to improve trial accrual, including centralising care where that is the best means to achieve trial accrual. This defines a common vision that can lead to improved outcomes for AYA with cancer in Europe.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103533/

Sanlaville C, Loiseau Médecin Généraliste A, Colin C, Salmon PK, Letrilliart L.

Abstract:                                                                                                                                                                                                                                              

Diagnosis of cognitive disorders is at medical and ethical stake. The aim of an qualitative study based on interviews was to explore the views of general practitioners on this diagnosis. General practitioners are ambivalent about the relevance and temporality of the diagnosis of cognitive disorders, which could be resolved by a shared decision making at each stage of the diagnostic approach.

https://pubmed.ncbi.nlm.nih.gov/34304810/

- Cyrille Colin, Asma Fares, Pascale Guerre : « Realist Evaluation »

"Realist evaluation is an increasingly popular methodology in health qervuces research" said Trisha Greenalgh in BMJ 2015. It is a form of theory-driven evaluation, that aims to understand why complex interventions in health services research work, how, for whom, in what context and to what extent. We will explore the context-mechanism-outcome relation using ethnographic observation, semi-structured interviews, and srutiny of documents and other contemporaneous materials. Examples of french innovations aiming at redesigning health care will be given.