La recherche au service de la performance en Santé
U.INSERM 1290 - La recherche au service de la performance en Santé
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Université Claude Bernard Lyon 1
U.INSERM 1290 - La recherche au service de la performance en Santé

Actualités du laboratoire Hesper

Development and Validation of a Predictive Model of Hypovitaminosis D in General Adult Population: SCOPYD Study.

Viprey M, Merle B, Riche B, Freyssenge J, Rippert P, Chakir MA, Thomas T, Malochet-Guinamand S, Cortet B, Breuil V, Chapurlat R, Lafage Proust MH, Carlier MC, Fassier JB, Haesebaert J, Caillet P, Rabilloud M, Schott AM.

Development and Validation of a Predictive Model of Hypovitaminosis D in General Adult Population: SCOPYD Study.

Background : The worldwide global increase in serum 25-hydroxyvitamin D (25(OH)D) measurements has led some countries to restrict reimbursement for certain clinical situations only. Another approach could consist in providing physicians with screening tools in order to better target blood test prescription. The objective of the SCOPYD study was to identify the best combination of predictors of serum VitD concentration among adults aged 18-70 years.

Methods:  Potential risk factors for VitD deficiency were collected using a comprehensive self-administered questionnaire. A multivariable linear regression was used to build a predictive model of serum 25(OH)D concentration. Among 2488 participants, 1080 (43.4%) had VitD deficiency (<50 nmol/L) and 195 (7.8%) had severe deficiency (<25 nmol/L). The final model included sunlight exposure in the preceding week and during the last holidays, month of blood sampling, age, sex, body mass index, skin phototype, employment, smoking, sport practice, latitude, and VitD supplementation in preceding year. The area under the curve was 0.82 (95% CI (0.78; 0.85)) for severe deficiency. The model predicted severe deficiency with a sensitivity of 77.9% (95% CI (69.1; 85.7)) and a specificity of 68.3% (95% CI (64.8; 71.9)). We identified a set of predictors of severe VitD deficiency that are easy to collect in routine that may help to better target patients for serum 25(OH)D concentration determination.

https://pubmed.ncbi.nlm.nih.gov/34444687/

Soutenance de thèse d'Adèle Perrin le 6 octobre 2021 à 14h Amphi C Site Rockefeller

Titre : Améliorer la prise en charge des patients à faible niveau de littératie en santé hospitalisés pour une pathologie cardiovasculaire chronique 

Sous la direction du Dr Julie Haesebaert

Réunion Scientifique 17 septembre 2021 à 12h30

 - Julie Freyssenge : « L’accès aux soins d’urgence : une approche territoriale »  

Dans un contexte d’augmentation de la fréquentation des services d’urgence, il est essentiel de comprendre les mécanismes de recours aux soins des populations. Nous proposons une approche territoriale des soins d’urgence prenant notamment en compte les bassins démographiques et la répartition spatiale des structures.

Nous traiterons des notions d’accessibilité et de disparités spatiales à travers différents projets régionaux traitant la notion de recours aux soins d’urgence, principalement lors de la phase préhospitalière.

 

Clinical characteristics and outcome of elderly patients admitted in emergency department with an oxygen mismatch and type 2 myocardial infarction or myocardial injury.

Jacquin L, Mewton N, Bosne S, Mantout A, Bergerot C, Tazarourte K, Douplat M.

Background: Aging is a risk factor for type 2 myocardial infarction or myocardial injury, but few data are available on the elderly. We aimed to determine the factors associated with these pathologies and mortality in the elderly population and its age classes.

Methods: A retrospective cohort of all patients with oxygen mismatch (anemia, hypoxia, tachycardia, hypo/hypertension) for whom a troponin drawn was performed at admission in 2 emergency departments. Medical records were reviewed and classified as having type 2 myocardial infarction, acute or chronic myocardial injury, or no myocardial injury.

https://pubmed.ncbi.nlm.nih.gov/34247343/